| 1. | - | | Charlotte Hooper
Chante Chatman
Adanna Thompson
Payton Ashe | 3:58.59a | FL | Gainesville | FHSAA Class 3A State Championship | Fri, May 4 |
| 2. | - | | Brianna Hurst
Michele Thomas
Mariah Bean
Kourtney Smith | 4:12.98a | FL | Leesburg | FHSAA Class 3A Region 1 Championship | Wed, Apr 25 |
| 3. | - | | Kaylyn Pitts
Gabi Paiz
Alexis Wells
Breanna Schmuck | 4:14.17a | FL | Matanzas | FHSAA Class 3A Region 1 Championship | Wed, Apr 25 |
| 4. | - | | Laquantis Burton
Ashlyn Dellheim
Aaliyah High
Kahlei Vanostran | 4:14.90 | FL | West Port | Florida Relays | Sat, Apr 7 |
| 5. | - | | Dynasty Cason
Valencia Paine
Charlese Bradford
Destinie Willis | 4:19.96a | FL | Mainland | FHSAA Class 3A Region 1 Championship | Wed, Apr 25 |
| 6. | - | | Relay Team | 4:27.44a | FL | Forest | Kowboy Invitational | Sat, Mar 10 |
| 7. | - | | Relay Team | 4:29.23a | FL | Lake Weir | FHSAA 3A District 4 Championship | Thu, Apr 19 |
| 8. | - | | Relay Team | 4:34.13a | FL | Deltona | Five Star Conference Championship | Fri, Mar 30 |
| 9. | - | | Relay Team | 4:35.03a | FL | Vanguard | FHSAA 3A District 4 Championship | Thu, Apr 19 |
