| 1. | - | | Relay Team | 48.32a | FL | Lake Brantley | FHSAA Class 4A State Championship | Sat, May 5 |
| 2. | - | | Jasmine Thomas
DaKesha Jackson
Ravyn Mike
Caitlin Stevison | 48.79a | FL | Sanford Seminole | FHSAA Class 4A Region 1 Championship | Thu, Apr 26 |
| 3. | - | | Hazel Lockard
Fendi Johnson
Cierra Fischer
Dee Dee Banks | 50.00a | FL | Viera (Melbourne) | Holy Trinity Elite Classic | Fri, Mar 30 |
| 4. | - | | Imani Keitt
Chantelle Rumph
Ebony Luster
Courtney Blanden | 50.25a | FL | Lake Mary | FHSAA Class 4A Region 1 Championship | Thu, Apr 26 |
| 5. | - | | Relay Team | 50.30a | FL | Spruce Creek | Five Star Conference Championship | Fri, Mar 30 |
| 6. | - | | Relay Team | 51.34a | FL | Hagerty | FHSAA 4A District 2 Championship | Wed, Apr 18 |
| 7. | - | | Relay Team | 51.64c | FL | Orange City University | Deland Quad Meet | Wed, Mar 7 |
| 8. | - | | Cassandr Barragan
Laycha Villanueva
Marivi Montero
Elma Montero | 53.99a | FL | Lake Howell | FHSAA 4A District 2 Championship | Wed, Apr 18 |
| 9. | - | | Cortini Brown
Alexis Moodie
Bianca Hardke
Jojet A Idawo | 54.57a | FL | Lyman | FHSAA 4A District 2 Championship | Wed, Apr 18 |
| 10. | - | | Relay Team | 55.57a | FL | DeLand | Five Star Conference Championship | Fri, Mar 30 |
