| 1. | - | | Caprisha Treadwell
Lashawntiana Brown
TaQuisha Drisdell
Astaria Perkins | 1:52.60 | IL | Chicago (North Lawndale Charter) | 2nd annual North Lawndale College Prep Relay | Sat, Apr 14 |
| 2. | - | | Relay Team | 1:53.39a | IL | Chicago (Morgan Park) | Windy City Classic Relays | Sat, Apr 21 |
| 3. | - | | Kaylee Miller
Erin Owens
Aarion Owens
Jordyn Looman | 1:54.47a | IL | Centralia | Edwardsville Relays | Wed, Apr 11 |
| 4. | - | | Relay Team | 1:54.97a | IL | Chicago (Brooks) | *CPS Varsity Championships | Sat, May 5 |
| 5. | - | | Relay Team | 1:55.25a | IL | Chicago (Lane) | *CPS Varsity Championships | Sat, May 5 |
| 6. | - | | Darshay Wallace
Jovannie Spears
Shanna Ramsey
Randi Robinson | 1:56.06a | IL | Chicago (Perspectives Charter/Calumet) | *CPS South Relays | Sat, Apr 7 |
| 7. | - | | Deshonia Garrett
Mechel Sanders
Ahmeel Betts
Monet Jennings | 1:56.10 | IL | Chicago (Simeon) | 2nd annual North Lawndale College Prep Relay | Sat, Apr 14 |
| 8. | - | | Relay Team | 1:56.66a | IL | Chicago (Dunbar) | Windy City Classic Relays | Sat, Apr 21 |
| 9. | - | | Caitlin Watts
Asha Woodfolk
Shianne Baggett
Queenster Nartey | 1:56.76a | IL | Chicago (Whitney Young) | *CPS Girls Varsity Trials | Tue, May 1 |
| 10. | - | | Relay Team | 1:57.30a | IL | Chillicothe (Illinois Valley Central) | Dunlap Relays | Fri, Apr 20 |
| 11. | - | | Keke Dawson
Serena Cunningham
Edraniel Tookes
Amina Jackson | 1:57.51a | IL | Lincoln | Olympia Relays | Tue, Apr 17 |
| 12. | - | | Janice Fults
Jamise Parish
Malik's McToy
Latina Taylor | 1:57.76a | IL | Chicago (Robeson) | *CPS South Relays | Sat, Apr 7 |
| 13. | - | | Relay Team | 1:57.90a | IL | Bartonville (Limestone) | Dunlap Relays | Fri, Apr 20 |
| 14. | - | | Delaree Jackson
Nyjae McNeal
Shaerra Harlan
Rachel Campbell | 1:58.00a | IL | East St. Louis (Sr.) | Rod Staggs Frosh-Soph | Mon, Mar 26 |
| 15. | - | | Relay Team | 1:58.28a | IL | Chicago (Harlan) | Windy City Classic Relays | Sat, Apr 21 |
| 16. | - | | Ariel Gibbs
Deidra Dockery
Samantha Somerville
Kathryn Graf | 1:58.60 | IL | Momence | Comet Carnival | Tue, Apr 17 |
| 17. | - | | Relay Team | 1:58.78a | IL | Annawan-Wethersfield | Dunlap Relays | Fri, Apr 20 |
| 18. | - | | Janina Car
Yakira Love
Nicole Young
Marielle Dickens | 1:59.10a | IL | Chicago (Westinghouse College Prep) | *CPS Girls Varsity Trials | Tue, May 1 |
| 19. | - | | Khatona Miller
Aiya Johnson
Gabriel Rahming
Miranda Dangerfield | 1:59.50 | IL | Chicago (Lincoln Park) | Lincoln Park Relays | Sat, Apr 21 |
| 20. | - | | Relay Team | 1:59.72a | IL | Mackinaw (Deer Creek) | Dunlap Relays | Fri, Apr 20 |
| 21. | - | | Alveta Moore
Georgia Strogger
Champale Grays
Demara Howard | 2:00.06a | IL | Chicago (Crane) | *CPS North Relays | Sat, Apr 7 |
| 22. | - | | Relay Team | 2:00.39a | IL | Dunlap | Dunlap Relays | Fri, Apr 20 |
| 23. | - | | Relay Team | 2:00.57a | IL | Princeton | Dunlap Relays | Fri, Apr 20 |
| 24. | - | | Relay Team | 2:01.00a | IL | Galesburg | Dunlap Relays | Fri, Apr 20 |
| 25. | - | | Relay Team | 2:01.41a | IL | Chicago (Kenwood) | *CPS Varsity Championships | Sat, May 5 |
| 26. | - | | Annette Mcmorries
Narvonia Dent
Andrea Fox
Zana Jackson | 2:01.60 | IL | Chicago (Orr) | Lady Spartan Invite | Wed, Apr 4 |
| 27. | - | | Holly Goetten
Kayla Schleper
Mary Claire Davis
Emalie Thornton | 2:01.80 | IL | Jerseyville (Jersey) | Roxana Relays | Mon, Apr 16 |
| 28. | - | | Relay Team | 2:02.66a | IL | Eureka | Dunlap Relays | Fri, Apr 20 |
| 29. | - | | Relay Team | 2:02.70a | IL | Farmington | Dunlap Relays | Fri, Apr 20 |
| 30. | - | | Claritza Maldonado
Chinue Wilford
Mia Harris
Khadijah Weathers | 2:03.30a | IL | Chicago (Payton) | *CPS Girls Varsity Trials | Tue, May 1 |
| 31. | - | | Kairah Garcia
Rhyan Sharkey
Victoria Hudson
Crystal Tucker | 2:04.00 | IL | Chicago (DuSable) | Lincoln Park Relays | Sat, Apr 21 |
| 32. | - | | Ashley Fischbach
Vanessa Ortega
Ashley Jones
Melissa Tassone | 2:05.3a | IL | Sandwich | Plainfield North Relay Invite | Sat, Apr 7 |
| 33. | - | | Relay Team | 2:05.50a | IL | Peoria (Notre Dame) | Dunlap Relays | Fri, Apr 20 |
| 34. | - | | Relay Team | 2:06.40 | IL | Chicago (Fenger) | 2nd Annual Warriors Invite | Sat, Apr 14 |
| 35. | - | | Nadja Thomas
Mercedes Binns
Ryan Preacely
Alexus McDonald | 2:06.80 | IL | Johnson College Prep | 2nd annual North Lawndale College Prep Relay | Sat, Apr 14 |
| 36. | - | | Alexandra Johnson
Azia Hollins
Sonja Intrizai
Sara Algawerash | 2:07.10 | IL | Wheaton (W. Warrenville South) | Prospect Relays | Thu, Apr 5 |
| 37. | - | | Angelica Lee
Myesha Coley
Dejanaie Matthews
Justice Plummer | 2:07.37a | IL | Chicago (Agricultural Science) | *CPS Girls Varsity Trials | Tue, May 1 |
| 38. | - | | Relay Team | 2:09.88a | IL | Chicago (Clark) | Windy City Classic Relays | Sat, Apr 21 |
| 39. | - | | Relay Team | 2:10.13a | IL | Chicago (King) | *CPS Girls Soph Championships | Fri, Apr 27 |
| 40. | - | | Shaquilla Jackson
Kwanisha Brown
Tangie Finner
Erica Gayden | 2:11.01a | IL | Englewood | *CPS South Relays | Sat, Apr 7 |
| 41. | - | | Hailey Potts
Marilyn Joines
Emilee Ellingsworth
Heather Perry | 2:12.10 | IL | Bridgeport (Red Hill) | Tiger Relays | Fri, Apr 20 |
| 42. | - | | Alicia Moore
Nia Brown
Emanuella Brookman
Kirsten Anderson | 2:12.33a | IL | Chicago (Von Steuben) | *CPS North Relays | Sat, Apr 7 |
| 43. | - | | Relay Team | 2:14.27a | IL | Chicago (Northside) | *CPS Girls Soph Championships | Fri, Apr 27 |
| 44. | - | | Relay Team | 2:14.80 | IL | Perspectives Charter IIT Math & Science | 2nd Annual Warriors Invite | Sat, Apr 14 |
| 45. | - | | Liyah Crumb
Angel Patterson
DeMerria Davis
Tiffany Duncan | 2:15.52a | IL | Percy L Julian | *CPS Girls Varsity Trials | Tue, May 1 |
| 46. | - | | Marissa Feldmann
Brittany Brackman
Taylor Gaudette
Sarah Sheffer | 2:17.70 | IL | Staunton | Litchfield Relays | Fri, Mar 23 |
| 47. | - | | Relay Team | 2:18.80 | IL | Chicago (Senn) | CPS North Conference Meet #2 | Wed, Apr 18 |
| 48. | - | | Carissa Allen
Khyanna Wright
Tia Terrell
Ebony Cattouse-Watson | 2:19.36a | IL | Chicago (C. Vocational) | *CPS South Relays | Sat, Apr 7 |
| 49. | - | | Relay Team | 2:22.70a | IL | Peoria | Dunlap Relays | Fri, Apr 20 |
| 50. | - | | Relay Team | 2:22.96a | IL | Chicago (Prosser) | Windy City Classic Relays | Sat, Apr 21 |
| 51. | - | | Sierra Miller
Nia Howard
Denisha Phillips
Ammaarah Yameen | 2:27.40 | IL | Chicago (Providence-St. Mel) | Lady Spartan Invite | Wed, Apr 4 |
| 52. | - | | Relay Team | 2:28.00 | IL | HFA Power House High | 2nd Annual Warriors Invite | Sat, Apr 14 |
| 53. | - | | Relay Team | 2:31.79a | IL | Chicago (Gage Park) | Windy City Classic Relays | Sat, Apr 21 |
| 54. | - | | Relay Team | 2:34.80 | IL | South Land College Prep | 2nd Annual Warriors Invite | Sat, Apr 14 |
| 55. | - | | Relay Team | 2:35.67a | IL | Chicago (Schurz) | *CPS Girls Soph Championships | Fri, Apr 27 |
| 56. | - | | Relay Team | 2:38.00 | IL | Gary Comer College Prep. | 2nd Annual Warriors Invite | Sat, Apr 14 |
| 57. | - | | Relay Team | 3:10.10a | IL | Tremont | Dunlap Relays | Fri, Apr 20 |
