| 1. | - | | Deshaun Jordan Tavaris Coleman Terry Magee Imani Payton | 1:34.20 | IL | Chicago (North Lawndale Charter) | 2nd annual North Lawndale College Prep Relay | Sat, Apr 14 |
| 2. | - | | Relay Team | 1:34.60 | IL | Chicago Heights (Bloom Twp.) | 2nd annual North Lawndale College Prep Relay | Sat, Apr 14 |
| 3. | - | | Relay Team | 1:34.91a | IL | Chicago (Dunbar) | Windy City Classic Relays | Sat, Apr 21 |
| 4. | - | | Spencer Williams Corey Mims Donnell Taylor Lonnie Washington | 1:36.69a | IL | Chicago (Perspectives Charter/Calumet) | *CPS South Relays | Sat, Apr 7 |
| 5. | - | | Ben Andreas Jack Myers Daniel Spaccapaniccia Sam Bransby | 1:36.80 | IL | Naperville (Central) | Rock Island Invitational | Fri, Apr 20 |
| 6. | - | | Quzara Prather Danan Beedie Peter Bremhorst Luke Farley | 1:37.10 | IL | Springfield | Raider Relays | Thu, May 3 |
| 7. | - | | Relay Team | 1:38.10 | IL | Chicago (Fenger) | 2nd Annual Warriors Invite | Sat, Apr 14 |
| 8. | - | | John Gardner Jabaree Winston Elijah Muhammad Darnell Cockwell | 1:38.30 | IL | Chicago (Simeon) | 2nd annual North Lawndale College Prep Relay | Sat, Apr 14 |
| 9. | - | | DeAndre Wright Eric Thomas Nick Hundley Kris Dagan | 1:39.30 | IL | Momence | Comet Carnival | Tue, Apr 17 |
| 10. | - | | Kanyea Sayon Edward Lubaga Prince Nimy Jamir Stovall | 1:39.90 | IL | Champaign (Central) | Raider Relays | Thu, May 3 |
| 11. | - | | Cameron Donaby Deante Smith Natereace Strong Jujan Askew | 1:39.99a | IL | East St. Louis (Sr.) | Rod Staggs Frosh-Soph | Mon, Mar 26 |
| 12. | - | | Justin Abram Jerome Fuller Deion Fields Timothy Smith | 1:40.83a | IL | Chicago (Morgan Park) | *CPS South Relays | Sat, Apr 7 |
| 13. | - | | Clarence Maxwell Mustapha Jallow Anthony Hudson Michael Gulan | 1:41.20 | IL | Chicago (Von Steuben) | 2nd annual North Lawndale College Prep Relay | Sat, Apr 14 |
| 14. | - | | Mayfield Alden Javon Brown Aldon Mayfield Clinton Wilson | 1:41.50 | IL | Chicago (Orr) | 2nd annual North Lawndale College Prep Relay | Sat, Apr 14 |
| 15. | - | | Relay Team | 1:41.79a | IL | Chicago (Robeson) | Windy City Classic Relays | Sat, Apr 21 |
| 16. | - | | Guito Wagenbach Laurence Simms Isaac Schweigert Eli Larimore | 1:42.10a | IL | Tremont | Richwoods | Thu, Mar 22 |
| 17. | - | | Absalom Boyd Carlos Singleton Chacuntary Jones James Graham | 1:42.50 | IL | Chicago (Westinghouse College Prep) | 2nd annual North Lawndale College Prep Relay | Sat, Apr 14 |
| 18. | - | | Brett Charlton Dylan Troyer Noah Zimmerman Tracy Myers | 1:43.20a | IL | Eureka | Richwoods | Thu, Mar 22 |
| - | | Marcus Pilman Brandon Tolliver-Goode Dylan Davidson Austin Angel | 1:43.20 | IL | Newton | Olney Invitational | Sat, Apr 7 |
| 20. | - | | Charlence McBride Antawon McCline Lincoln Austin Charles Bryant | 1:43.50 | IL | Chicago (Marshall) | Lincoln Park Relays | Sat, Apr 21 |
| 21. | - | | Relay Team | 1:44.00 | IL | Chicago (Senn) | CPS North Conference Meet #2 | Wed, Apr 18 |
| 22. | - | | Relay Team | 1:44.20a | IL | Chicago (Clark) | Windy City Classic Relays | Sat, Apr 21 |
| 23. | - | | Michael Anderson DiAndre Carracter Jamal Murphy Cortez Wallace | 1:44.70 | IL | Urban Prep Charter (West) | 2nd annual North Lawndale College Prep Relay | Sat, Apr 14 |
| 24. | - | | Vashan Critteden Michael Andrews Julius Morris Tobias Lee | 1:45.23a | IL | Chicago (Carver Military Academy) | *CPS South Relays | Sat, Apr 7 |
| 25. | - | | Kendall Morris Dewayne Collins Adonis Childs T'Andre Miles | 1:45.70 | IL | Wendell Phillips | 2nd annual North Lawndale College Prep Relay | Sat, Apr 14 |
| 26. | - | | Adam Mongold Nicholas Ondes Dylan Bertels Lucas Meyer | 1:46.20a | IL | Staunton | Carlinville Relays | Tue, Apr 17 |
| 27. | - | | Zac Young Jake Jepson Max Balagna Kyle Harmon | 1:46.70a | IL | Farmington | Richwoods | Thu, Mar 22 |
| 28. | - | | Reginald Torian Patrick Dunn Darius Patterson Kenneth Crosby | 1:47.38a | IL | Chicago (Brooks) | *CPS South Relays | Sat, Apr 7 |
| 29. | - | | Marcellus Gee Antonio Robinson Kentrell Arthur Kevon Harris | 1:47.56a | IL | Chicago (Corliss) | *CPS South Relays | Sat, Apr 7 |
| 30. | - | | Rowdy Freeland Cornelious Bell Gareth Miller Eric McCausland | 1:48.10 | IL | Charleston | Olney Invitational | Sat, Apr 7 |
| - | | Antonyio Barton Kendall Whitehead Mike Steveson Damoni Ware | 1:48.10a | IL | Chicago (Harper) | *CPS South Relays | Sat, Apr 7 |
| 32. | - | | Logan Kirby Drew Leathers Jerimiah Wyatt Avery Neace | 1:49.90a | IL | Dunlap | Richwoods | Thu, Mar 22 |
| 33. | - | | Relay Team | 1:50.30 | IL | Gary Comer College Prep. | 2nd Annual Warriors Invite | Sat, Apr 14 |
| - | | Relay Team | 1:50.30 | IL | HFA Power House High | 2nd Annual Warriors Invite | Sat, Apr 14 |
| - | | Brayce Hardy Jahleel Griffin Tyre Dukes Ryon Riddle | 1:50.30 | IL | Perspectives Charter IIT Math & Science | 2nd Annual Warriors Invite | Sat, Apr 14 |
| 36. | - | | Evan Schlink Alex Koester Devin Niebrugge Riley Drees | 1:51.70 | IL | Teutopolis | Olney Invitational | Sat, Apr 7 |
| 37. | - | | Nick Bleichner Nick Miller Ryan Teichman Kellin Rollins | 1:52.00a | IL | Bloomington (Central Catholic) | Richwoods | Thu, Mar 22 |
| 38. | - | | Relay Team | 1:52.18a | IL | Chicago (Gage Park) | Windy City Classic Relays | Sat, Apr 21 |
| 39. | - | | Dontay Boddie Brandon Ruffin Benjamin Harris Derick Heerman | 1:53.20a | IL | Peoria | Richwoods | Thu, Mar 22 |
| 40. | - | | Jaquan Carr Ahmad Alexander Terell Durham DaMarlon Morris | 1:53.96a | IL | Percy L Julian | *CPS South Relays | Sat, Apr 7 |
| 41. | - | | Thichin Spencer Marquez Cartham Jeremy Harris Robert Price | 1:54.47a | IL | Englewood | *CPS South Relays | Sat, Apr 7 |
| 42. | - | | Brendon Bullard Blake Woodward Blake Cebulske Bryce Meigs | 1:54.50 | IL | Salem | Olney Invitational | Sat, Apr 7 |
| 43. | - | | Guadalupe Mendoza Francisco Diaz Salvador Solis Daniel Diaz | 1:54.93a | IL | Juarez | *CPS North Relays | Sat, Apr 7 |
| 44. | - | | Cedric Malone Brandon James DeVonte` Rimmer Anthony Ash | 1:54.96a | IL | Chicago (King) | *CPS South Relays | Sat, Apr 7 |
| 45. | - | | Edwin Duran Marco Silva Josue Torres Eric Lora | 1:55.78a | IL | Chicago (Steinmetz) | *CPS North Relays | Sat, Apr 7 |
| 46. | - | | William Mendez Jonathan Miller Michael Hill Brandon Johnson | 2:01.13a | IL | Chicago (Foreman) | *CPS North Relays | Sat, Apr 7 |
| 47. | - | | Relay Team | 2:01.18a | IL | Chicago (Prosser) | Windy City Classic Relays | Sat, Apr 21 |
| 48. | - | | Fausto Galindo David Nava Jose Lopez Alvaro Alba | 2:01.62a | IL | Chicago (Schurz) | *CPS North Relays | Sat, Apr 7 |
| 49. | - | | Relay Team | 2:02.60a | IL | Annawan-Wethersfield | Richwoods | Thu, Mar 22 |
| 50. | - | | Jaime Quito Marco Cortes Antonio Tellez Alejandro Gonzalez | 2:08.51a | IL | Chicago (Hancock) | *CPS South Relays | Sat, Apr 7 |
| 51. | - | | Linus Erkenswick Scott Gould Remardo Wilson Derrick Terry | 2:09.29a | IL | Chicago (Ogden International) | *CPS North Relays | Sat, Apr 7 |