| 1. | - | | Jessica McCaskill
Sidne' Williamson
Chante Mosby
Aniecia Brewster | 47.55a | IL | Belleville (East) | IHSA Girls Class 3A State Championships | Fri, May 18 |
| 2. | - | | Mystique Thompson
LaCresha Linton
Troy Jackson
Jalea Jackson | 47.57a | IL | Rock Island | IHSA Girls Class 3A State Championships | Fri, May 18 |
| 3. | - | | Kristyon Tolliver
Tatyana Lewis
Asia Cochran
Abrea Hopson | 47.91a | IL | Belleville (West) | IHSA Girls Class 3A State Championships | Fri, May 18 |
| 4. | - | | Brandy Griffin
Markita Rush
Rheyana Branch
Nijia McNamee | 48.27a | IL | East St. Louis (Sr.) | IHSA Girls Class 3A State Championships | Fri, May 18 |
| 5. | - | | Tashia McClenton
Denesha Swift
Jayda Hill
Aleasha Jones | 48.64a | IL | O'Fallon | IHSA Girls Class 3A State Championships | Fri, May 18 |
| 6. | - | | Siera Rallo
Meih Huddleston
Morgan Sharpe
Kristen Dowell | 48.71a | IL | Edwardsville | IHSA Girls Class 3A State Championships | Fri, May 18 |
| 7. | - | | Relay Team | 49.65a | IL | Springfield | CS-8 Girl's Conference Meet(SH-G Host) | Thu, May 3 |
| 8. | - | | Brianna French
Ciara Little
Shatavia Lowery
Autumn Vergeyle | 51.70a | IL | East Moline (United) | Western Big 6 Girls Conference Meet | Fri, May 4 |
| 9. | - | | Sadie Lipe
Kourtney Marks
Tashawna Nash
Kyvierra Hawkins | 51.72a | IL | Peoria (Richwoods) | Rock Island Girls ABC Invitational | Sat, Apr 14 |
| 10. | - | | Ashley Cooley
Sata Cisse
Hailey Cook
Lindsey Fuller | 52.31a | IL | Moline | Western Big 6 Girls Conference Meet | Fri, May 4 |
| 11. | - | | Lexy Freed
Alexis Read
Savannah Schaber
Paige Schwiderski | 52.94a | IL | Normal (Community) | Metamora Co Ed Invite | Sat, Apr 7 |
| 12. | - | | Kelsey Marshall
Jordan Williams
Mary Puzauskas
D'Onna Stokes | 53.12a | IL | Normal (Community West) | Metamora Co Ed Invite | Sat, Apr 7 |
| 13. | - | | Relay Team | 53.76a | IL | Bloomington | Big 12 Girls Conference | Fri, May 4 |
| 14. | - | | Relay Team | 54.09a | IL | Pekin | MI Conference - GIRLS | Thu, May 3 |
