| 1. | 12 | | Margaret Bamgbose | 41.11a | IL | Evanston (Twp.) | IHSA Girls Class 3A State Championships | Fri, May 18 |
| 2. | 11 | | Sunshine Simon | 46.02a | IL | Skokie (Niles West) | IHSA 3A Sectional | Thu, May 10 |
| 3. | 10 | | Olivia Cattau | 46.81a | IL | Park Ridge (Maine South) | IHSA 3A Sectional | Thu, May 10 |
| 4. | 12 | | Melissa Jones | 47.17a | IL | Mt. Prospect (Prospect) | IHSA 3A Sectional | Thu, May 10 |
| 5. | 10 | | Carrie White | 48.05a | IL | Evanston (Twp.) | IHSA 3A Sectional | Thu, May 10 |
| 6. | 9 | | Hannah Hess | 48.78a | IL | Wilmette (Loyola Academy) | Girls Catholic Athletic Conference Championships | Sat, May 5 |
| 7. | 11 | | Jenny Koh | 48.80a | IL | Skokie (Niles North) | IHSA 3A Sectional | Thu, May 10 |
| 8. | 11 | | Dana Hanken | 49.66a | IL | Winnetka (New Trier) | IHSA 3A Sectional | Thu, May 10 |
| 9. | 9 | | Maggie McPike | 49.69a | IL | Wilmette (Loyola Academy) | IHSA 3A Sectional | Thu, May 10 |
| 10. | 10 | | Serina Lodhia | 49.71a | IL | Skokie (Niles West) | IHSA 3A Sectional | Thu, May 10 |
| 11. | 12 | | Emily Stern | 49.94a | IL | Highland Park | IHSA 3A Sectional | Thu, May 10 |
| 12. | 11 | | Sunbright Simon | 50.39a | IL | Skokie (Niles West) | Ram Invitation | Sat, Apr 21 |
| 13. | 10 | | Kate Henry | 50.45a | IL | Deerfield | IHSA 3A Sectional | Thu, May 10 |
| 14. | 11 | | D'anna Conway | 50.61a | IL | Chicago (Mather) | IHSA 3A Sectional | Thu, May 10 |
| 15. | 10 | | Tara Stokes | 50.80a | IL | Mt. Prospect (Prospect) | IHSA 3A Sectional | Thu, May 10 |
| 16. | 11 | | Francesca Castelli | 50.92a | IL | Highland Park | IHSA 3A Sectional | Thu, May 10 |
| 17. | 9 | | Remy Amarteifio | 51.10a | IL | Evanston (Twp.) | CSL Girls Conference Meet | Fri, May 4 |
| 18. | 9 | | Cassandra Banas | 51.13a | IL | Park Ridge (Maine South) | CSL Girls Conference Meet | Fri, May 4 |
| 19. | 11 | | Maggie Devereux | 51.42a | IL | Mt. Prospect (Prospect) | Mid Suburban League (MSL) Girls Championship | Fri, May 4 |
| 20. | 10 | | Megan Petrey | 51.47a | IL | Deerfield | IHSA 3A Sectional | Thu, May 10 |
| 21. | 11 | | Katie Dwyer | 51.99a | IL | Glenview (Glenbrook South) | CSL Girls Conference Meet | Fri, May 4 |
| 22. | 10 | | Hannah Waldman | 52.59a | IL | Winnetka (New Trier) | CSL Girls Conference Meet | Fri, May 4 |
| 23. | 9 | | Amanda Ly | 53.02a | IL | Skokie (Niles North) | IHSA 3A Sectional | Thu, May 10 |
| 24. | 10 | | Sahar Khalid | 53.46a | IL | Skokie (Niles West) | CSL Girls Conference Meet | Fri, May 4 |
| 25. | 9 | | Taylor Newmark | 54.06a | IL | Winnetka (New Trier) | Metea Valley Girls Invite | Sat, Apr 7 |
| 26. | 12 | | Tori Walley | 54.54a | IL | Park Ridge (Maine East) | IHSA 3A Sectional | Thu, May 10 |
| 27. | - | | Lexi Hasan | 54.71a | IL | Park Ridge (Maine South) | CSL Girls Conference Meet | Fri, May 4 |
| 28. | 9 | | Maria Du | 55.01a | IL | Chicago (Mather) | Mather Invitational | Sat, Mar 31 |
| 29. | 10 | | Stefani Gutmann | 55.14c | IL | Deerfield | Wauconda Girls' Track and Field Invitational | Fri, Apr 20 |
| 30. | 10 | | Abbey Riportella | 55.48a | IL | Des Plaines (Maine West) | IHSA 3A Sectional | Thu, May 10 |
| 31. | 12 | | Kristin Georgopoulos | 55.66a | IL | Park Ridge (Maine East) | IHSA 3A Sectional | Thu, May 10 |
| 32. | 9 | | Katie Wells | 56.21a | IL | Glenview (Glenbrook South) | WW South Invitational | Fri, Apr 13 |
| 33. | 9 | | Casey Figueredo | 56.54a | IL | Winnetka (New Trier) | CSL Girls Conference Meet | Fri, May 4 |
| 34. | - | | Jen Mocarski | 56.76a | IL | Park Ridge (Maine South) | CSL Girls Conference Meet | Fri, May 4 |
| 35. | 10 | | Lauren Wendtland | 57.40a | IL | Des Plaines (Maine West) | IHSA 3A Sectional | Thu, May 10 |
| 36. | 11 | | Kelly Salinas | 57.41a | IL | Northbrook (Glenbrook North) | IHSA 3A Sectional | Thu, May 10 |
| 37. | 11 | | Julia Weilandt | 62.02a | IL | Winnetka (New Trier) | CSL Girls Conference Meet | Fri, May 4 |
| 38. | 11 | | Natalie Wall | 63.25a | IL | Glenview (Glenbrook South) | CSL Girls Conference Meet | Fri, May 4 |
