| 1. | - | | Molly Chelovitz
Isabelle Horning
Bryanna Renuart
Megan Hissong | 2:08.00 | OH | St. Hilary | Dioc of Clev CYO - Hoban HS | Sun, May 6 |
| 2. | - | | Katie Bachmann
Jenna Kupcik
Madison Stubbendieck
Mallorie Rohrbach | 2:10.00 | OH | St. Francis Xavier | Dioc of Clev CYO - Villa Angela St. Joseph HS | Sun, May 13 |
| 3. | - | | Carley Spencer
Lauren Keyser
Katelyn McDowell
Katherine McRaven | 2:17.00 | OH | Holy Family-Stow | Dioc of Clev CYO - Barberton HS | Sun, Apr 22 |
| 4. | - | | Lexie Spring
Marissa Kastelic
Anna Ruscak
Helena Krejsa | 2:21.00 | OH | St. Sebastian | Dioc of Clev CYO - Univ of Akron | Sun, Apr 22 |
| 5. | - | | Jillian Catalano
Emily Hershberger
Danielle Severns
Quincy Powers | 2:21.10 | OH | St. Matthew | Dioc of Clev CYO South Area Champ | Mon, May 14 |
| 6. | - | | Sophia Ricard
Alexis Wakeling
Gina Villanti
Abby Wickerham | 2:23.10 | OH | Seton Catholic | Dioc of Clev CYO - Univ of Akron | Sun, Apr 29 |
| 7. | - | | Morgan Pulling
Kelsey McDowell
Elaina Balit
Mikayla Foster | 2:29.00 | OH | Immaculate Heart of Mary | Dioc of Clev CYO - Walsh Jesuit HS | Sun, May 6 |
| 8. | - | | Anna Fields
Allisen Hansen
Alena Miskinis
Ellie Edwards | 2:30.20 | OH | Spring Garden | Dioc of Clev CYO - Hoban HS | Sun, Apr 29 |
| 9. | - | | Morgan Ciccotelli
Chloe Zelch
Kathryn Coughlin
Zoe Zelch | 2:31.30 | OH | Our Lady of the Elms | Dioc of Clev CYO - Hoban HS | Sun, May 6 |
| 10. | - | | Sydney Harrison
Janjit Skello
Shelly Bradshaw
Landry McVicker | 2:52.70 | OH | St. Francis de Sales | Dioc of Clev CYO - Hoban HS | Sun, Apr 29 |
| 11. | - | | Sara Lenzo
Anna Parham
Caley Scahill
Nina Zaynor | 2:57.00 | OH | St. Patrick | Dioc of Clev CYO - Kent State | Sun, Apr 15 |
