| 1. | - | Kelsey Beard
Zamecia Marshall
Joi Townsend
Heather Williams | 49.36a | Gateway | |
| 2. | - | Marlisa Stevenson
Monique Sandford
Shaniqua Moore
Tiffeney Cannon | 50.46a | Beaumont | |
| 3. | - | Vonteria Applewhite
Daqueisheanna Howard
Allisha Oglesby
Chazeton Redd | 50.48a | Sikeston | |
| 4. | - | Brooke Baker
Lindsey Hindman
Taylor Martin
Samantha Midgett | 51.11a | Dexter | |
| 5. | - | Kelsey Lee
Hien Nguyen
Alatra Wansley
Abby Reynolds | 51.12a | Desoto | |
| 6. | - | Josselyn Adams
Aireyon Clem
Suaddah Irvin-Muhammad
Aiesha Irvin-Muhammad | 51.30a | St Elizabeth Academy | |
| 7. | - | Destinee Harris
Taylor Brockmiller
Jodi Brandenburg
Miranda McKelvey | 51.49a | Farmington | |
| 8. | - | Amber Daniels
Brandi Moorehead
Anchevia Noble
Alexis Smith | 51.87a | Miller Career Academy | |
| 1. | - | Taylor Porter
Hali Ford
Shawna Carmack
Cheyenne Hoerr | 1:45.06a | Affton | |
| 2. | - | Anchevia Noble
Amber Daniels
Marlesha Gilard
Alecia Herndon | 1:47.08a | Miller Career Academy | |
| 3. | - | Kelsey Lee
Deanna Peters
Abby Reynolds
Alatra Wansley | 1:47.27a | Desoto | |
| 4. | - | Vonteria Applewhite
Daqueisheanna Howard
Allisha Oglesby
Chazeton Redd | 1:47.72a | Sikeston | |
| 5. | - | Destinee Harris
Emily Harris
Taylor Brockmiller
Miranda McKelvey | 1:48.80a | Farmington | |
| 6. | - | Marissa Cage
Makayla Campbell
Annie Gardner
Paige Mooney | 1:48.97a | Windsor | |
| 7. | - | Brooke Baker
Christina Harris
Lindsey Hindman
Taylor Martin | 1:50.23a | Dexter | |
| 8. | - | Josselyn Adams
Aireyon Clem
Suaddah Irvin-Muhammad
Aiesha Irvin-Muhammad | 1:53.41a | St Elizabeth Academy | |
| 1. | - | Kia Brimer
Tia Brimer
Sadiyah Mumin
Alicia Bell | 4:06.06a | Soldan International... | |
| 2. | - | Emily Harris
Jetaime Hovis
Taylor Brockmiller
Alexis Kiefer | 4:07.89a | Farmington | |
| 3. | - | Kaitlyn Emig
Sarah Ross
Megan Campbell
Gabby Hantak | 4:08.69a | Rosati-Kain | |
| 4. | - | Nicole Beffa
Crystal Beffa
Lainey Foltz
Jamie Kempher | 4:08.98a | Festus | |
| 5. | - | Candace Burr
Kristen Faulkner
Morgan Grither
Molly Huck | 4:10.98a | Sainte Genevieve Sen... | |
| 6. | - | Maranda Akers
Haley Davis
Heidi Knuckles
Olivia Meyer | 4:11.98a | Hillsboro | |
| 7. | - | Marissa Cage
Makayla Campbell
Maria Miloscia
Paige Mooney | 4:12.32a | Windsor | |
| 8. | - | Lauren Dalton
Dana Kaempfe
Taylor Kirchwehm
Amanda Behnke | 4:12.53a | Lutheran South | |
| 1. | - | Crystal Beffa
Sadie Darnell
Jamie Kempher
Nicole Beffa | 9:37.85a | Festus | |
| 2. | - | Alexis Kiefer
Emily Harris
Jetaime Hovis
Jacqueline Wolf | 9:50.20a | Farmington | |
| 3. | - | Kristen Faulkner
Morgan Grither
Molly Huck
Shelby Werner | 10:00.77a | Sainte Genevieve Sen... | |
| 4. | - | Alissah Dickey
Kierstin Godier
Alison Parks
Megan Parks | 10:02.86a | North County | |
| 5. | - | Becca Hairer
Kathy McCormack
Shawna Carmack
Cheyenne Hoerr | 10:22.74a | Affton | |
| 6. | - | Alicia Bell
Kia Brimer
Tia Brimer
Jasmine Diltz | 10:29.67a | Soldan International... | |
| 7. | - | Sarah Ross
Alex Holzum
Maddie Campbell
Megan Campbell | 11:10.06a | Rosati-Kain | |
