| 1. | - | Christina Pasyk Whitney Freeman Jessica Goodrich Shakyla Askew | 49.39a | Munster | |
| 2. | - | Andrea Alvarez Kaitlyn Moricz Samantha Stewart Isis Thomas | 50.29a | Lake Central | |
| 3. | - | Shermika Winston Brechey White Jazmyn Thomas Brianna Thompson | 50.30a | Merrillville | |
| 4. | - | Denisha Golston Arielle Borders Kenya Jordan Samantha Smith | 50.41a | Lew Wallace | |
| 5. | - | Kassidy Swenson Paige Huck Claudia Kalin Steffanie Long | 50.64a | Valparaiso | |
| 6. | - | Brittany Brown Kemi Doss Jasmine Reed Daria Goodwin | 50.74a | Gary Roosevelt | |
| 7. | - | Carlie Erne Mariaha Flowers Kelsie Zawada Denisha Mitchell | 50.75a | LaPorte | |
| 8. | - | Destiny Ryan Kylie Mikus Carly Kiran Jamie Hovanec | 50.86a | Crown Point | |
| 9. | - | Anna Raffin Ari Mahaffey Catherine Pannekoek Katie Urycki | 50.93a | Chesterton | |
| 10. | - | Ashley Smith Ashley Farley Jabria Ezell Kristy Evans | 51.06a | Portage | |
| 11. | - | Jalisa Slate Kimberly Johnson Skylar Mata Anitta McLaurin | 52.02a | Hammond Morton | |
| 12. | - | Jordan Brandt Rachael Franko Kathryn Sommers Farrer Sabec | 52.33a | Winamac Community | |
| 13. | - | Makenna Hamilton Alexandria Gudeman Carlee Davis Marissa Hamilton | 53.47a | West Central | |
| 14. | - | Terriyon Pena Courtney Harrison Emily Surma Megan Block | 54.65a | No Judson-San Pierre | |
| -- | - | Courtney Osby Jasmine Turner Jana Prochaska Abby Walker | DNF | Morgan Township | |
| -- | - | Katherine Smailis Shaughnessy Magee Julia Wiesemann Airrica Harper | DNF | Highland | |
| 1. | - | Alana Eatinger Isis Thomas Shannen Reynolds Andrea Alvarez | 3:59.61a | Lake Central | |
| 2. | - | Colleen Boyle Jessica Goodrich Allison Boyle Whitney Freeman | 4:02.77a | Munster | |
| 3. | - | Mercedez Washington Kortney Mabone Ja'Liza Prophet Beatrice Turpin | 4:03.25a | Gary West Side | |
| 4. | - | Katie Behrendt Megan Behrendt Shauna Foor Tori Schroeder | 4:06.45a | Chesterton | |
| 5. | - | Whitney Mitchell Abi Small Augusta Schrader Bailey Beckham | 4:06.50a | Crown Point | |
| 6. | - | Blaney Keough Kassidy Swenson Kimberly Walker Sara Tumbas | 4:07.02a | Valparaiso | |
| 7. | - | Brianna Thompson Breyana Russ Kiara McLaurin Taishe Abrams | 4:10.41a | Merrillville | |
| 8. | - | Mary Gamble Sarah Thompson Kirstin Lestinsky Haley Sheedy | 4:12.49a | New Prairie | |
| 9. | - | Briana Lewin Laura MacNeill Alixandra Shircliff Paige Hickenbottom | 4:14.46a | Hebron | |
| 10. | - | Kimberly Johnson Ellen Jennisis Sanford Cyerra Sims Jennifer Sanford | 4:15.22a | Hammond Morton | |
| 11. | - | Anna Sacco Ashley Ulanowski Tori Nida Jordan Lump | 4:15.22a | Lowell | |
| 11. | - | Anna Sacco Ashley Ulanowski Victoria Nida Jordan Lump | 4:15.81a | Lowell | |
| 12. | - | Brooklyn Judge Joslin Robinson Aubria Clifton Kiara Hernandez | 4:20.01a | Michigan City | |
| 13. | - | Jorden Dellahan Mallory DeFries Angel Zentz Dayton Dellahan | 4:25.37a | Kankakee Valley | |
| 14. | - | Samantha Marker Billie Reitz Caitlyn Brown Brianna Nelson | 4:25.72a | Griffith | |
| 15. | - | Terriyon Pena Emily Surma Megan Block Courtney Harrison | 4:25.93a | No Judson-San Pierre | |
| 16. | - | Emerald Blankenship Kathryn Sommers Emily Pulsen Danyell Bailey | 4:34.16a | Winamac Community | |
| 1. | - | Allison Boyle Lyndsey Kunz Colleen Boyle Kyela Specht | 9:30.82a | Munster | |
| 2. | - | Megan Plenus Alaina Willis Anna Kacius Dana Payonk | 9:35.81a | Lake Central | |
| 3. | - | Lauren McCarroll Augusta Schrader Xia Meng Howey Laicee Pierce | 9:43.72a | Crown Point | |
| 4. | - | Mary Gamble Julie Jeszenszky Mary McBride Sarah Thompson | 9:50.26a | New Prairie | |
| 5. | - | Lauren Bigger Tricia Joll Tiffany Fortney Janelle Golly | 9:59.48a | Valparaiso | |
| 6. | - | Billie Reitz Caitlyn Brown Victoria Anderson Taylor Austin | 10:24.67a | Griffith | |
| 7. | - | Brianna Martinez Rebekah Wojkovich Beth Conley Alyssa Adelsperger | 10:25.80a | Andrean | |
| 8. | - | Abby Trader Paige Mulle Megan Ambler Brianne Cipich | 10:36.37a | Portage | |
| 9. | - | Jorden Dellahan Coral Justice Felicia Sytsma Dayton Dellahan | 10:37.10a | Kankakee Valley | |
| 10. | - | Jordan Hanaway Emily DeFries Laura MacNeill Trisha Hanlon | 10:39.03a | Hebron | |
| 11. | - | Carrie Chelich Kylee Miller Sara Jackson Emilee Vode | 10:43.54a | Hobart | |
| 12. | - | Rosie Biehl Sarah Bobby Elise Gustafson Riley Trella | 10:50.58a | Chesterton | |
| 13. | - | Rebekkah Serrano Cyerra Sims Yvonne Mireles Jennifer Sanford | 10:52.53a | Hammond Morton | |
| 14. | - | Chelsea Cook Casey Boose Rachael Dobson Lesley Park | 10:56.78a | Rensselaer Central | |
| 15. | - | Jhane Nolan Ashley Bebley DeAughania Wheeler Asya Tomlin | 11:09.57a | Gary West Side | |
| 16. | - | Holly Buckman Emily Surma Kendall Gardner Olivia Lickwar | 11:09.66a | No Judson-San Pierre | |