| 1. | - | Kim Mitchell
Paige Biles
Alana Hester
Laura King | 49.46a | Eureka | |
| 2. | - | Lianna Doty
Amanda Krupnik
Lindsey Leeker
Bria McWoods | 49.90a | Kirkwood | |
| 3. | - | Nicole Douglas
Cierra Griffin
Paula Harden
Sierra Scott | 50.09a | Parkway West | |
| 4. | - | Liz Buneta
Jaime Doggendorf
Taylor Hosna
Emily Weiss | 50.48a | Northwest | |
| 5. | - | Emily Broadhacker
Anna Curran
Tyler Ishmon
Caitlin Merkel | 50.58a | Lindbergh | |
| 6. | - | Claire Anglo
Katie Grunik
Mary Kate Mullen
Emily Murphy | 50.62a | Cor Jesu Academy | |
| -- | - | Kayla Little
Asya Taylor
Chelsy Gibson
Imani Myton | DQ | Parkway Central | |
| -- | - | Rashae Allen
Aretha Fowler
Jashuan Melton
Crystal Harris | DQ | Rockwood Summit | |
| 1. | - | Shayla Arnold
Alexis Brisco
Kenesha Austin
Nicole McNicols | 1:41.01a | Ladue Horton Watkins | |
| 2. | - | Lindsey Leeker
Bria McWoods
Amber Solomon
Elisa Steele | 1:43.52a | Kirkwood | |
| 3. | - | Paige Biles
Ashley Gerkens
Alana Hester
Laura King | 1:44.13a | Eureka | |
| 4. | - | Liz Buneta
Jaime Doggendorf
Taylor Hosna
Emily Weiss | 1:45.15a | Northwest | |
| 5. | - | Anastasia Harris
Heather Meyer
Patricia Miller
Hannah Snyder | 1:46.18a | Lafayette (Wildwood) | |
| 6. | - | Emily Broadhacker
Kelly Clark
Anna Curran
Tyler Ishmon | 1:48.61a | Lindbergh | |
| 7. | - | Claire Anglo
Katie Grunik
Melanie Hosty
Christie Lewis | 1:49.08a | Cor Jesu Academy | |
| 8. | - | Lauren Anderson
Hollie Adelmund
Mary Ann Bradshaw
Paige Brown | 1:49.52a | Jackson | |
| 1. | - | Kenesha Austin
Alexis Brisco
Montenea Roye
Shayla Arnold | 3:55.12a | Ladue Horton Watkins | |
| 2. | - | Alyssa Rebecca
Jill Rechtein
Jessie McNeel
Kelsey Brown | 3:59.24a | Eureka | |
| 3. | - | Paige Blasberg
Erica Dyroff
Lianna Doty
Lindsey Leeker | 3:59.82a | Kirkwood | |
| 4. | - | Paige Trachsel
Jamie Teague
Sidney Baudendistel
Crystal Harris | 4:01.47a | Rockwood Summit | |
| 5. | - | Katie Jost
Imani Myton
Courtney Engel
Chelsy Gibson | 4:04.02a | Parkway Central | |
| 6. | - | Sophia Meyer
Colleen Riley
Grace Watt
Marina White | 4:06.29a | Lindbergh | |
| 7. | - | Mary Ann Bradshaw
Paige Brown
Taylor Dickerson
Landon Wachter | 4:08.84a | Jackson | |
| 8. | - | Megan Auer
Kelsea Boone
Caitlyn Brinkmann
Nekole Harvey | 4:11.11a | Oakville Senior | |
| 1. | - | Lianna Doty
Hannah Richardson
Elizabeth Luciani
Elizabeth King | 9:21.81a | Kirkwood | |
| 2. | - | Taylor Schulz
Aimee Westrich
Kelsey Brown
Jessie McNeel | 9:24.53a | Eureka | |
| 3. | - | Connie Bevirt
Sophia Meyer
Colleen Riley
Grace Watt | 9:27.94a | Lindbergh | |
| 4. | - | Jamie Teague
Rebekah Lawson
Alyssa Jones
Jenny Govero | 9:34.06a | Rockwood Summit | |
| 5. | - | Katie Jost
Taylor Burke
Jessica Airey
Diane Robison | 9:39.92a | Parkway Central | |
| 6. | - | Brittany Boone
Kayla Hall
Alexa Lipke
Jessica Maddox | 9:43.83a | Lafayette (Wildwood) | |
| 7. | - | Meg Buckley
Kelsey Cihota
Elise Viox
Carolyn G'Sell | 10:30.24a | Cor Jesu Academy | |
| 8. | - | Kendra Bollinger
Lindsey Seabaugh
Zhao Ni Dirnberger
Megan Keesee | 10:56.42a | Jackson | |
