| 1. | | Demario Jordan
Carl Edwards
Jeremy Gardner
Christopher Maxwell | 41.95a | - | SC | Blythewood | SCHSL Class AAAA State Championships | Sat, May 16 |
| 2. | | Relay Team | 42.20a | - | SC | Berkeley | SCHSL Class AAAA State Championships | Sat, May 16 |
| 3. | | Roderick McDowell
Romaine Prince
Terrell Titus
Timmy Rogers | 42.32a | - | SC | Sumter | SCHSL Class AAAA State Championships | Sat, May 16 |
| 4. | | Relay Team | 42.34a | - | SC | West Ashley | Region 8 Class 4A | Wed, Apr 29 |
| 5. | | Tony Brown-Thompson
Jaquan Thomas
Josh Brown
Raymond Eurie | 42.38a | - | SC | James Island | SCHSL Class AAAA State Championships | Sat, May 16 |
| 6. | | Relay Team | 42.54a | - | SC | Crestwood | SCHSL Class AAA State Championships | Sat, May 16 |
| 7. | | Marques Moore
Cody Reese
Seth McGinnis
Michael Thomas | 42.58a | - | SC | Summerville | SCHSL Class AAAA State Championships | Sat, May 16 |
| 8. | | Relay Team | 42.60a | - | SC | Airport | SCHSL Class AAA State Championships | Sat, May 16 |
| 9. | | Jerante Hood
Daymon Price
Jatavious Stewart
Daniel Pressley | 42.65a | - | SC | Rock Hill | SCHSL Class AAAA State Championships | Sat, May 16 |
| 10. | | Rashad Mallett
Eric Jones
Gavin Sumter
Thomas Gallman | 42.75a | - | SC | Irmo | Taco Bell Meet | Sat, Apr 11 |
| 11. | | Daventran Cromer
Ladarius Simpson
Jimmy Harris
Javarous Cunningham | 42.94c | - | SC | Laurens | Regional 1 Class AAAA | Thu, Apr 30 |
| 12. | | Relay Team | 43.00a | - | SC | Beaufort | Region 8 Class 4A | Wed, Apr 29 |
| 13. | | Relay Team | 43.13a | - | SC | Mid-Carolina | SCHSL Class AA State Championships | Sat, May 16 |
| 14. | | Relay Team | 43.29a | - | SC | Fort Dorchester | Region 8 Class 4A | Wed, Apr 29 |
| 15. | | Relay Team | 43.32a | - | SC | Wilson | Taco Bell Invitational Meet | Sat, Apr 11 |
| 16. | | Relay Team | 43.39a | - | SC | Woodland | SCHSL Class AA State Championships | Sat, May 16 |
| 17. | | Relay Team | 43.40a | - | SC | Eau Claire | SCHSL Class AA State Championships | Sat, May 16 |
| 18. | | Relay Team | 43.41a | - | SC | Chesnee | SCHSL Class AA State Championships | Sat, May 16 |
| 19. | | Relay Team | 43.44a | - | SC | Lake Marion | SCHSL Class AAA State Championships | Sat, May 16 |
| 20. | | Relay Team | 43.50a | - | SC | Bluffton | SCHSL Class AAA State Championships | Sat, May 16 |
| 21. | | Relay Team | 43.54c | - | SC | TL Hanna | HANNA VS WESTSIDE | Thu, Apr 16 |
| | Byron Best
Ajani Burton
DJ Swearinger
Sam Montgomery | 43.54c | - | SC | Greenwood | Regional 1 Class AAAA | Thu, Apr 30 |
| 23. | | Brett Smith
Melvin Lewis
Deandre Jones
Zach Parker | 43.56a | - | SC | South Aiken | SCHSL Class AAA State Championships | Sat, May 16 |
| 24. | | Relay Team | 43.62a | - | SC | Andrews | SCHSL Class AA State Championships | Sat, May 16 |
| 25. | | Relay Team | 43.74c | - | SC | Easley | Easley HS @ Regional AAAA Event | Thu, Apr 30 |
| | Relay Team | 43.74a | - | SC | Allendale-Fairfax | SCHSL Class A State Championships | Sat, May 16 |
| 27. | | Treves Bush
Martinez Gallman
Chris Blocker
Darjuanarius Meriwheather | 43.75a | - | SC | Strom Thurmond | SCHSL Class AA State Championships | Sat, May 16 |
| 28. | | Relay Team | 43.77a | - | SC | Hemingway | SCHSL Class A State Championships | Sat, May 16 |
| | Relay Team | 43.77a | - | SC | Ridge View | Taco Bell Invitational Meet | Sat, Apr 11 |
| 30. | | Zachary Barber
Ernest Talford
Terrel Hutchinson
Terrence Jeter | 43.79a | - | SC | Great Falls | SCHSL Class A State Championships | Sat, May 16 |
| | Relay Team | 43.79a | - | SC | Battery Creek | Taco Bell Invitational Meet | Sat, Apr 11 |
| 32. | | Brandon Johnson
Zach Duskin
Henry Mack
Jurell Flippen | 43.84c | - | SC | Dutch Fork | Irmo vs Dutch Fork | Wed, Apr 1 |
| 33. | | John Miller
Shawn Hardy
Daniel Green
Marcos Pearson | 43.88a | - | SC | Manning | SCHSL Class AA State Championships | Sat, May 16 |
| 34. | | Relay Team | 44.02a | - | SC | Spring Valley | Taco Bell Invitational Meet | Sat, Apr 11 |
| 35. | | Relay Team | 44.11a | - | SC | White Knoll | Taco Bell Invitational Meet | Sat, Apr 11 |
| 36. | | Josh Sanga
Johnathon Day
Joe Rister
Jalen Pauling | 44.14c | - | SC | Chapin | Chapin @ Lower Richland | Tue, Mar 31 |
| 37. | | Thomas Meadows
Devin Jackson
Charles Turner
Troy Sanders | 44.25a | - | SC | Chester | SCHSL Class AAA State Championships | Sat, May 16 |
| 38. | | Jalen Elrod
BJ Palmer
Sidney Rhodes
Nick Coffield | 44.44c | - | SC | Wren | Regional 1 Class AAAA | Thu, Apr 30 |
| 39. | | Keenan Fleming
Kaylan Adams
William Pope
Alex James | 44.54a | - | SC | Aiken | Boys Region 5 AAAA Meet | Thu, Apr 30 |
| | Jalen Hunter
Dyland Williams
Hakim Martin
KeNeyl Tubman | 44.54c | - | SC | Westside | Regional 1 Class AAAA | Thu, Apr 30 |
| 41. | | Relay Team | 44.72a | - | SC | Union County | Taco Bell Invitational Meet | Sat, Apr 11 |
| 42. | | Relay Team | 44.76a | - | SC | Cross | SCHSL Class A State Championships | Sat, May 16 |
| 43. | | Relay Team | 45.01a | - | SC | Hammond | SCISA State Championships | Sat, May 2 |
| 44. | | Traceston Robinson
Terigaus Fambrough
Torrance Bryant
Deriyus Harper | 45.08a | - | SC | McCormick | SCHSL Class A State Championships | Sat, May 16 |
| 45. | | Darius Paulk
Crys Harmon
Levell Kirkland
Alexander Green | 45.16a | - | SC | Richland Northeast | Boys Region 5 AAAA Meet | Thu, Apr 30 |
| 46. | | Marquell Palmer
Christopher Hames
Brenton Bonner
Daryl Geter | 45.19a | - | SC | Blacksburg | SCHSL Class A State Championships | Sat, May 16 |
| 47. | | Marc Braswell
Dillon Calvert
Wesley Wells
Nathan McQueen | 45.24c | - | SC | Liberty | Region I-AA Pre-Region Meet | Tue, Mar 31 |
| 48. | | Ben Downs
Shon Lark
Trae Abney
DeAndre Reed | 45.47a | - | SC | Ninety-Six | SCHSL Class A State Championships | Sat, May 16 |
| | Relay Team | 45.47a | - | SC | West Florence | Taco Bell Invitational Meet | Sat, Apr 11 |
| 50. | | Fritz Simmons
Jared Holloway
Henry Taylor
Cameron West | 45.64c | - | SC | Cane Bay | Cane Bay vs Woodland. Kingstree, Cross, Lake Marion, Garrett, St Johns | Wed, Mar 11 |
| | Relay Team | 45.64a | - | SC | JL Mann | Taco Bell Invitational Meet | Sat, Apr 11 |
| 52. | | Relay Team | 45.73a | - | SC | Orangeburg Prep | SCISA State Championships | Sat, May 2 |
| 53. | | James Lowery
Josh Glenn
Robert Rohner
Blane Russell | 45.93a | - | SC | Wilson Hall | SCISA State Championships | Sat, May 2 |
| 54. | | Corey Kupitz
Addison Fisher
Cameron Hoover
Matthew Rogers | 46.32a | - | GA | Augusta Christian | SCISA State meet | Sat, May 2 |
| 55. | | Relay Team | 46.43a | - | SC | Heathwood Hall | SCISA State Championships | Sat, May 2 |
| 56. | | Shannon Stone
Hakeem Flowers
Mike Roberts
Rasheb Poole | 46.54a | - | SC | Wade Hampton - Greenville | SCHSL Class AAA State Championships | Sat, May 16 |
| 57. | | Clarence Williams
Tavarus Porter
Shaun Thomas
Thomas Flowers | 46.74c | - | SC | North Central | Class A District 3 Region Meet | Mon, Apr 27 |
| 58. | | Relay Team | 46.83a | - | SC | Ben Lippen | SCISA State Championships | Sat, May 2 |
| 59. | | Relay Team | 47.77a | - | SC | Laurence Manning Academy | SCISA State Championships | Sat, May 2 |
| 60. | | Jordan Green
Duvonte Blocker
Marcus Hodges
B.J. Hampleton | 47.98a | - | SC | Colleton County | Region 8 Class 4A | Wed, Apr 29 |